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Taking too much glutamate can cause seizures and kill brain cells

Abbreviations AKT1: RAC-alpha serine/threonine-protein kinase BMI: Body Mass Index CpG: Cytosine-phosphate-Guanine dinucleotide DESeq2: Differential Expression analysis based on the Negative Binomial distribution DNA: Deoxyribonucleic Acid DMSO: Dimethyl Sulfoxide FDR: False Discovery Rate FC: Fold Change GSEA: Gene Set Enrichment Analysis GO: Gene Ontology GRCh38: Genome Reference Consortium Human Build 38 IPA: Ingenuity Pathway Analysis KEGG: Kyoto Encyclopedia of Genes and Genomes LP: Lipedema Patient HC: Healthy Control MTBE: Methyl-t-butyl ether NMR: Nuclear Magnetic Resonance PLS-DA: Partial Least Squares Discriminant Analysis RIN: RNA Integrity Number RNA: Ribonucleic Acid RNA-Seq: RNA Sequencing SD: Standard Deviation SOP: Standard Operating Procedure STAR: Spliced Transcripts Alignment to a Reference TCA: Tricarboxylic Acid (cycle) TSS: Transcription Start Site TSP-d4: 2,2,3,3-d4-trimethylsilyl-propionic acid sodium salt UTR: Untranslated Region VIP: Variable Importance in Projection References Herbst KL, Kahn LA, Iker E, Ehrlich C, Wright T, McHutchison L, Schwartz J, Sleigh M, Donahue PM, Lisson KH, et al