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Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

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Walker et al., 2010), mitochondrial associated membrane (MAM) dysfunction (Watanabe et al., 2016), ER-Golgi transport defects (Atkin et al., 2015), autophagy dysregulation and apoptosis (Ravits et al., 2013