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Oral lipoic acid supplements are better absorbed on an empty stomach than with food: taking lipoic acid with food (versus without food) decreased peak plasma lipoic acid concentrations by about 30% and total plasma lipoic acid concentrations by about 20% (8)

Novel levodopa formulations and delivery modes address these issues and include novel oral ER formulations as well as non-oral approaches like an inhalation powder for intrapulmonary delivery for on-demand treatment of OFF-episodes and soluble formulations for continuous subcutaneous infusion to control motor fluctuations

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