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As shown in Figure 4-3, stratification to a subgroup level represents a first step in the transition from the one-size-fits-all model to a precision-based model

However, the lack of significant statistical interaction between subgroups (P = 0.127) suggests that addition of the AMPLITUDE-O trial has not changed the previous scenario [5], stressing that the net separation on MACE effect between patients with or without established CV disease may be more nuanced than suggested by previous meta-analyses [3]

Other minor effects include [6]: Uneven skin pigmentation Nail pigmentation Facial flushing Headache Alteration of taste More serious side effects are rare and may include [6]: Acute priapism requiring medical intervention Heart palpitations Hematoma Abdominal pain Hyperventilation Dizziness Seizures Melanoma Clinicians caution against the use of melanotan 2 in subjects with body dysmorphic disorders, particularly as related to skin tone

Glutathione, as a potent antioxidant, helps neutralize free radicals, reducing oxidative damage to the skin cells