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Side effects of semaglutide may include nausea, vomiting, constipation, gallbladder problems, and low blood sugar

[2] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors, [23] [24] and the US FDA package insert carries a warning to this effect, [2] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated

However, if you do only want to use one, then it depends what skin concerns you want ton target

The Cryolipolysis device provides controlled cooling in the target area and crystallizes the fat cells