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Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency

Some of the symptoms include: Constant tiredness Weakness Brain fog Tingling in the feet or hands Anxiety or moodiness Pale skin Poor memory If you experience any of these symptoms and youre concerned, speaking to a Private Medical in West Ealing is the best way to get a better understanding of your health condition and determine if you have a B12 deficiency

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Two studies investigated the ACC/mPFC and one of these studies found increased glutamine/glutamate ratio [40] while the other found no significant abnormalities in glutamate levels in schizophrenia [41]