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In U937 cells, BBR (20 g/mL) downregulated genes of inflammatory pathways including advanced-glycation end products (AGE)- receptors for AGEs (RAGE) and IL-6, PTGS2, caspase (CASP)3, mitogen-activated protein kinase (MAPK)-1, and IL-1, and inhibited S

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Research from the journal Experimental Gerontology describes a theory where deteriorating melatonin rhythms cause other circadian rhythms to weaken and desynchronize, contributing significantly to the aging process itself and rendering the body more susceptible to age-related diseases