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For larger botanical molecules, specialized carrier systems are needed to get through the skin barrier effectively

The management of the condition primarily focuses on symptomatic and supportive treatment, including dietary restriction (restricting amino acids and odd-chain unsaturated fats as precursor substances for propionic acid), carnitine supplementation, and the use of metronidazole and other antibiotics to inhibit intestinal bacteria [20]

NET components degrade the endothelial glycocalyx, impair shearstress-mediated eNOS activation, and increase endothelial permeability, thereby exposing the subendothelial matrix and activating platelets [86]

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