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A variety of external factors including nutrients in the environment interacting with genetic susceptibility influence the accumulation of mutations in cells

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It can be readily absorbed through the skin, respiratory tract, and gastrointestinal systems, leading to respiratory, neurological, cardiovascular, and urinary disorders [3]

Keywords: neutrophils, neutrophil extracellular traps, gouty arthritis, inflammation, NETs inhibitor Graphical Abstract Introduction Gouty arthritis (GA) is an inflammatory arthritis caused by abnormal monosodium urate (MSU) deposition that occurred in joints and peripheral tissues 1 Ample evidence has suggested that the incidence and prevalence of GA are increasing around the world, 2 bringing burdens on health systems