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Membrane-incorporated PUFAs serve as primary targets for ROS-mediated oxidation, with their oxidative susceptibility increasing proportionally to the number of conjugated double bonds (Rouzer and Marnett, 2003), following the initiation of oxidation, free radicals exhibit dual propagation mechanisms: intramolecular migration within lipid bilayers or intermolecular chain reactions amplifying oxidative damage (Samovich et al., 2024)

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doi: 10.3389/fphar.2014.00181 Received 31 May 2014 Accepted 16 July 2014 Published 11 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Marc Diederich, Laboratoire de Biologie Molculaire et Cellulaire du Cancer, Hpital Kirchberg, Luxembourg

in multiple mouse models of obesity, this led to a decrease in body weight and the correction of dyslipidemia [141]