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For example, reduced levels of SCFAs (like butyrate, which is normally made by good bacteria) can weaken the BBB, making the brain more vulnerable to harmful substances

For spinal structures with naturally limited blood supply (particularly the intervertebral discs, which are largely avascular), this enhanced circulation to surrounding tissues can make a meaningful difference in healing capacity

MOTs-C may pose significant risk for immunogenicity for some routes of administration, the agency said in 2023

Limitations : Invasive with risks (e.g., hypoparathyroidism, recurrent laryngeal nerve damage), necessitates lifelong thyroid hormone replacement therapy