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After establishing a 5-day PCPA-induced insomnia model, treatments were administered over a subsequent 7-day period

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The main limiting factor for vitamin C supplements is gastrointestinal tolerance, as excessive supplementation can cause loose stools

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The post-needling topical reaches fibroblasts directly through open channels

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It is well established that triple-negative breast cancer (TNBC) is highly aggressive [22], with significantly higher rates of metastasis and recurrence compared to other breast cancer subtypes [23], especially in isceral and brain metastasis [24]

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