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Its only when arterial walls are inflamed (from insulin resistance, smoking, hypertension, oxidative stress, or metabolic dysfunction) that LDL penetration and oxidation become problematic

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This extended profile is what differentiates it from shorter-acting variants and makes it highly relevant in hormonal regulation and metabolic research frameworks

An observational study [31] spanning 28 years and involving 4,513 patients with type 2 diabetes revealed that the incidence of DR significantly increased with the duration of diabetes