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The primary outcomes were the one-year cumulative incidence of acute coronary syndromes, coronary artery disease encounters, heart failure, stroke, and all-cause mortality, assessed both during treatment and after discontinuation

Biosimilar development is the medium-term democratization opportunity Biocon Biologics, Samsung Bioepis, and other biosimilar developers are advancing semaglutide biosimilar programs that, upon patent expiry, could reduce drug costs by 70-85% and dramatically expand patient access in both developed markets with coverage barriers and developing markets with affordability constraints

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In this line of evidence, an experimental study using an established mouse model, demonstrated that moderate Se deficiency reduced messenger RNA (mRNA) expression of selenoprotein N (SELENON), a selenoprotein that plays an important role in early embryogenesis, and of SELENOP [60]