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Building on these tools, new dual agonist fluorescent probes such as daLUXendins enable the simultaneous investigation of GLP1R and GIPR (glucose-dependent insulinotropic polypeptide receptor), a critical advancement for studies on multi-agonist therapeutics in diabetes and obesity

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Muscle Integrity Models: In models of muscle-wasting conditions (e.g., dystrophic or disuse models), IGF-1 LR3 is used as a probe to evaluate how enhanced IGF signaling might affect muscle-cell survival, differentiation, and turnover dynamics