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These include: Pre-existing constipation or slow transit constipation Inadequate dietary fibre intake Insufficient fluid consumption Reduced physical activity levels Concurrent medications with constipating effects (such as opioids, certain antidepressants, or iron supplements) Older age , where baseline colonic motility may already be reduced The severity of constipation often correlates with the dose of medication and may be more pronounced during dose escalation phases

Hepatoprotective potential of Aloe vera polysaccharides against chronic alcoholinduced hepatotoxicity in mice

The effects of thiamine Tetrahydrofurfuryl disulfide upon the movement of the isolated small intestine

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver