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56 Apart from debris removal and resolution of injury, macrophages might play an important and very early role in hepatocyte proliferation after APAP-induced liver injury, based on the facts that macrophages are known to produce mitogens such as HGF, TGF-, platelet-derived growth factor, TNF-, and IL-6 and that proliferation occurs first after APAP toxicity in a layer of hepatocytes surrounding the necrotic zones, where macrophages actively infiltrate and proliferate.12, 22 In contrast, macrophages can also produce mito-inhibitory factors such as TGF-, which inhibits liver regeneration after APAP toxicity

Based on your results, your provider can use their clinical judgment to adjust your dose or recommend lifestyle changes

This places Pfizer directly in competition with established players like Novo Nordisk and Eli Lilly, whose GLP-1 products have already reshaped the obesity treatment market

Fracassi, A