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Specifically, gut microbiota dysbiosis, such as increased abundance of Proteobacteria and Actinobacteria and decreased numbers of Bacteroidetes , Prevotella and Firmicutes phyla , reduces the expression of tight junction protein genes, directly leading to the impairment of intestinal barrier function, making harmful microbiota and microorganisms pass through the intestinal barrier, stimulating the immune system and inducing immune cell inflammation, and ultimately accelerating NAFLD and liver fibrosis (58, 59)

- Week 2: Noticeably brighter complexion with improved smoothness

With proper nutritional support and monitoring, most patients can minimize or prevent this side effect entirely

Ferroptosis, a non-apoptotic form of programmed cell death (PCD), is closely related to NAFLD and HCC, and the mechanisms of action involved are more complex