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3 Rapid eye movement sleep behavior disorder (RBD) represents the most specific prodromal marker of PD, conferring over 90% risk of phenoconversion to -synucleinopathies, predominantly PD, over a 14-year follow-up period

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27 Free radical generation In addition, NADPH is also responsible for the generation of free radicals by NADPH oxidases (NOX) as a substrate

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