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244 Berberine alleviates diabetes-induced pain by inhibiting transient receptor potential vanilloid 1 (TRPV1) and the PKC pathway, reducing inflammation (Fig

Ozempic often used off-label) Tirzepatide (Zepbound / Mounjaro) a dual GLP-1/GIP agonist that tends to produce even greater weight loss Liraglutide (Saxenda) Originally developed for Type 2 diabetes, these medications received Health Canada approval for chronic weight management in adults with a BMI 30, or BMI 27 with at least one weight-related condition (such as hypertension, dyslipidemia, or obstructive sleep apnea)