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While an exact cause is unknown, slow intestinal transit may be the result of a combination of changes in the activity of colonic nerves, muscles, or interstitial cells of Cajal (ICC), which are the pacemakers of the gastrointestinal (GI) tract

We then performed sequence alignment of PDS5B 1308-1394 against the equivalent region in several PDS5B orthologs to identify conserved lysine and arginine residues that could be involved in interactions with the negatively charged phosphodiester backbone of DNA

The theory is that lower doses maintain results with fewer side effects

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