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Safety and unknowns GLP-1 drugs are strong medicines: Common side effects: nausea, vomiting, diarrhoea, constipation Possible nutrition issues if eating becomes very limited Limited data around implantation and very early pregnancy

They can be expensive and have serious side effects

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The SELECT trial (N=17,604) demonstrated that semaglutide 2.4 mg reduced the composite endpoint of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke by 20% in adults with established cardiovascular disease and overweight or obesity, independent of diabetes status (HR 0.80