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Tirzepatide is the only licenced GLP-1/GIP co-agonist for obesity, with several more GLP-1/GIP co-agonists in development [15]

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Highly infiltrative growth patterns, cellular and molecular heterogeneity, a subpopulation of cells highly resistant to radiotherapy and chemotherapy, called glioma stem-like or glioma-initiating cells 3,4,5,6 , and a complex network of interactions between different tumor cell populations and the tumor microenvironment 7 have been held responsible for escape from current therapies