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Metabolite concentrations were then normalized by the tissue weight
175-181 The finding that the administration of all-trans retinoic acid (ATRA) in elastase-induced emphysema in rats reversed the emphysematous changes, 182 suggested that ATRA might be a beneficial therapy for patients with emphysema
These autologous systems provide the opportunity to assess pharmacokinetic and pharmacodynamic relationships and guide therapeutic decisions by anticipating individual absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles
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