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One human study found that it boosted mitochondrial function in older adults with bad mitochondria, but that didnt translate to any changes in fatigue resistance

Skin Aging Of all the organs, the skin is the most conspicuous to display signs of aging or dermal changes, which are due to chronological (intrinsic) and photoaging (extrinsic) mechanisms [2, 10, 14]

The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases