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Criteria for inclusion and exclusion This study incorporated only those investigations that fulfilled specific inclusion criteria: publications in the English language, studies involving subjects diagnosed with type 2 diabetes mellitus (T2D), randomized controlled trials (RCTs), interventions that compared the efficacy of SGLT-2 inhibitors or GLP-1 receptor agonists against placebo, and reports on major adverse cardiovascular events (MACE) or hospitalization for heart failure (HHF), as well as cardiovascular outcomes irrespective of baseline metformin usage

[27] In accordance with the expression of GLP-1 receptor on brainstem and hypothalamus, GLP-1 has been shown to promote satiety and thereby reduce food and water intake