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The model of CTR: rAmy (CT-like, PDB: 7TYI) was used as the initial template for the CTR:Cagri/CagriBB complex in the CT-like conformation by replacement of the peptide

In other words, the body produces carnosine molecules at lower rates because it doesnt have enough beta-alanine

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Astroglial atrophy and loss of function A widespread class of astrocytic changes observed in many neurological diseases and in the majority of neuropsychiatric disorders are represented by structural atrophy and functional asthenia and manifested in the loss of key homoeostatic functions, such as for example glutamate clearance