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The investigators assessed molecular markers associated with autophagy, apoptosis, insulin-like growth factor signaling, oxidative stress, and histological integrity in skeletal muscle tissue to clarify whether GHRP-6 has protective or modulatory effects under conditions of DOX-induced damage

In addition, our previous studies revealed that microglia and their purinergic receptors (P2 4R, P2 7R and P2Y12R) were significantly upregulated in the TNC after NTG injection, and inhibiting microglial activation, including morphological and inflammatory changes, might affect neuronal hyperexcitability in the TNC, which ultimately relieved CM-associated allodynia [17,18,19]

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