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Poor Diet : Diets low in sulfur-containing amino acids and other glutathione precursors hinder its synthesis
Human TrxR1 (the cytosolic isoform) displays 74% sequence identity in the doorstop pocket residues with respect to TGR
The tumor microenvironment undergoes a vital transformation from a pro-metastatic condition to a restrictive state as the combined inhibition of VEGF and MMP signaling obstructs tumor-stromal interactions, resulting in reduced metastatic spread
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