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For example, when the amount of mtROS produced by mitochondria changes due to hypoxia, mtROS enhances anaerobic respiration by stabilizing HIF-1 and up-regulating key enzymes of glycolysis such as lactate dehydrogenase, reduces the dependence of cells on OXPHOS during hypoxia, and reduces the further production of mtROS

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However, the biotransformation of selenium into selenodiglutathione (GSSeSG) inside the vacuole does not contribute toward the reduction of its toxicity