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In conclusion, the current study revealed that arogenate-specific TyrA a enzymes evolved in some bacterial lineages, through the acquisition of an acidic residue at the 222 position, which later gave rise to the TyrAs of algae and land plants likely through a novel HGT event

Operating as a high-affinity positive allosteric modulator of Hepatocyte Growth Factor (HGF), Dihexa binds HGF to potentiate c-Met receptor tyrosine kinase signaling

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