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Ketogenic nutritional therapies alone have shown promise in promoting significant weight loss and improving BC
This was represented by the significant increase in the serum level of IL-6 and hippocampal tissue expression of TNF- in the diabetic group as compared to the CG
Phase 3 trials of CagriSema demonstrated: 15.6% body weight loss with the combination versus 8.1% with semaglutide alone Superior glycemic control compared to either component individually Manageable side effect profile with proper dose titration Regulatory submissions completed in 2024 for obesity treatment [6] Since retatrutide includes GLP-1 receptor activation (similar to semaglutide) plus additional GIP and glucagon receptor effects, the theoretical cagrilintide blend with retatrutide could potentially exceed even the impressive CagriSema results
Can J Kidney Health Dis 2023;10:20543581221149710
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