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In a two-step procedure, 2-hydroxymalondialdehyde is firstly condensed with p -aminobenzoyl-L-glutamic acid, forming a diimine, which subsequently reacts with triamino-pyrimidinone to obtain folic acid

Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, and Wagtmann N

Acknowledgements This paper was funded by grants from the National Natural Science Foundation of China (82070588, 82370577), National Key R&D Program of China (2023YFA1800801)