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Then, SUMO attachments are removed by SUMO-specific isopeptidases just like UCHs and UBPs remove ubiquitin from substrate proteins

Thus, NACs neuroprotective effects may involve its ability to reduce cortical spermidine levels and thereby limit local excitotoxic effects in the PFC during THC exposure, further indicated by our electrophysiological findings demonstrating a hyperactive neuronal mPFC phenotype

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