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5 Safety, clinical tolerability, and periconception management strategies From the perspective of actionable clinical management, this section categorizes three core challenges associated with the use of GLP-1RAs in women of reproductive age with PCOS: (i) discontinuity in adherence driven by gastrointestinal adverse effects

Large randomized trials designed to detect rare adverse events are mostly absent in this area

It mimics GH's lipolytic effects, promoting fat breakdown and inhibiting new fat formation, while early research suggests it preferentially acts on adipose tissue without significantly affecting IGF-1 or systemic GH levels

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