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Estrogen-Dependent Signaling Pathways and Cellular Effects Classical Estrogen Receptors In the 1960s, the group of Jensen and coworkers detected an intracellular protein in ovarian tissue able to interact with E2: the estrogen receptor (ER) (Jensen et al., 2010)
By performing gene set enrichment analysis (GSEA) limited to human-derived reads, we confirmed the upregulation of senescence and IFN- response signatures on palbociclib treatment and their downregulation when compared with palbociclib + RSL3-treated mice (Fig
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