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Dihydroartemisinin can induce ferroptosis in PDAC cells, and dihydroartemisinin combined with cisplatin can cause catastrophic accumulation of free iron and mitochondria-derived ROS in PDAC cells and lipid peroxidation, and impaired mitochondrial homeostasis, 187 indicating ferroptosis can increase the cytotoxicity of cisplatin to PDAC cells and overcome PDAC cisplatin resistance

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Last but not least, inflammation modulation also contributes to vascular protection