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(3) from arcade 2 to the next arcade (arcade 3) to the last arcade inside the ligations (or the previous ligation) (2-3, Figures 2, 5-8, 21 and 22)

So the benefit is real, but it is indirect and it depends on whether you were low to begin with

Key loci include immune-modifying genes such as human leukocyte antigens (HLA class I and II) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)