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Taylor, D

Two new classes of agents are being developed to take advantage of the unique glucoregulatory potential of GLP-1: The incretin mimetics, such as exenatide (synthetic exendin-4, a peptide resistant to proteolytic cleavage by DPP-IV) or derivatives of GLP-1 (created by chemical modification of the native hormone, to render them resistant to rapid proteolytic cleavage by DPP-IV), targeting the pharmacological effects, and insufficient secretion of GLP-1 seen in type 2 diabetes

Typical weight loss goals when taking medications are one pound of weight loss per week, with a 4% to 5% weight loss achieved after three to six months of taking the medication

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