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The semaglutide versus tirzepatide comparison page outlines the differences between the two main GLP-1 compounds, while the decision between drops and injections comes down to individual physiology and lifestyle preferences

2024;134(2):e175634

May 2024: Judge Gene E

Key results: 15 mg dose: Average weight loss of 22.5 percent (approximately 52 pounds for a 230-pound individual) 10 mg dose: Average weight loss of 21.4 percent 5 mg dose: Average weight loss of 16.0 percent Over 85 percent of participants at 10 mg or 15 mg lost at least 10 percent of body weight Over 50 percent at 15 mg lost at least 20 percent SURMOUNT-5, a head-to-head trial comparing tirzepatide to semaglutide, confirmed tirzepatides superiority at matched doses