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However, most of those people were overweight or obese when they started taking the medication, and its not clear if the medication is the cause of the weight gain

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Up-regulation of peroxisome proliferator-activated receptors (PPAR) and PPAR messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-responsive adipose tissue-specific genes in the liver of obese diabetic mice

What to Eat on a GLP1 Diet Lean Protein Sources Protein helps preserve muscle mass, improves satiety, and supports metabolism during weight loss