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Vascular conditions : Systemic hypertension,, high cholesterol levels, diabetes and hardening of the arteries can reduce blood flow to the optic nerve Anatomical predisposition : Having a small optic disc with a low cup-to-disc ratio creates a crowded disc appearance Nocturnal hypotension : Significant drops in blood pressure during sleep can decrease blood flow to the optic nerve head Sleep apnea : Intermittent episodes of low oxygen levels and problems with blood vessels during sleep increase the risk of ischemia Risk Factors and Complexity Show Why it is Hard to Predict Susceptible Patients: These various risk factors highlight how complex NAION is and why its challenging to predict who will be more susceptible to it