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Therefore, the observation that BPC-157 interacts with the NO system should be interpreted as a mechanistic clue, not as a complete explanation of all reported effects
Under physiological conditions, Nrf2 translocates from the cytoplasm to the nucleus upon oxidative challenge, binding to ARE sequences to induce expression of protective genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase catalytic subunit (GCLC) (Xu et al., 2023
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257, L163 (1989) , (3) V
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