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The 1919 GBM presented TERT and EGFR mutations, low expression of HES5 and unmethylated MGMT, while the 2012 GBM is characterized by CDK4 and MDM2 hallmark mutations, high expression of HES5 and unmethylated MGMT

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Whereas autophagy can degrade large macromolecular complexes and even entire organelles, the UPS is characterized by exquisite substrate specificity, targeting only ubiquitinated proteins while preserving intact cellular structures