The ultimate goal is the development of next-generation agents
Recent studies have reported that the development of heart failure in adolescents is closely associated with a dramatic increase in DM, obesity, and metabolic dysfunction-associated steatotic liver disease (MASLD) (Wu et al., 2024

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As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease