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Sermorelin's FDA Journey: Approved, Discontinued, and Compounded Sermorelin acetate (Geref) was FDA-approved in 1997 for pediatric GHD 1 and in 1990 for diagnostic use.26 The manufacturer discontinued Geref in 2008 due to "manufacturing difficulties," not safety or efficacy concerns.12 In 2013, the FDA confirmed it wasn't withdrawn for safety/effectiveness, allowing for potential generic approvals.12 Currently, Sermorelin is primarily available as a compounded medication 3, which is permitted but not individually FDA-approved like mass-produced drugs.22 5.2

The peptide works through multiple pathways including growth hormone receptor activation, angiogenesis promotion, and fibroblast migration to damaged tissue

It emits a combination of red- and blue-light therapy and massages the scalp to help stimulate hair follicles to start growing again

Your healthcare provider can help you determine whether oral or injectable semaglutide may be a better fit for you, based on your personal health situation and goals