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Quantification of -cell mass and total insulin content Islet -cell mass was measured as insulin-positive areas in IHC sections separated by 400 m to obtain a stereological analysis of the pancreas

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If those six things are solid and your weight and labs have been stable for at least three months, a slow taper, dose reduced in steps over eight to twelve weeks, with close follow-up, becomes reasonable

Conversely, other studies raise concerns about potential metabolic slowdown and negative impacts on weight loss sustainability, particularly in long-term fasting or in vulnerable populations such as women of reproductive age or individuals with subclinical hypothyroidism [9]