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Semaglutide and orforglipron act on the same single targetso this group may have maintained weight loss better after switching treatments, but they started with a less dramatic weight loss

Because these drugs affect the central nervous system, mental-health outcomes are a foreseeable safety issue, even if the precise level of risk remains uncertain

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Novo Nordisk and other manufacturers of the hugely popular weight loss drugs have been competing against compounding pharmacies, some clinics and medical spas who sell cheaper versions of the branded medications