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More conservative dose limits, such as 2000 mg per day, have been recommended, especially for patients in whom the liver disease is marked with hepatic decompensation or active alcohol abuse.21 Pregnancy APAP is considered the most frequently prescribed analgesic in pregnancy.46 Pregnancy is a high-risk state for many medications, and APAP is no exception

Therefore, in addition to GSSG accumulation, a decrease in Grx expression/activity may also lead to increased protein S -glutathionylation

The liver metabolizes alcohol at an average rate of one standard drink per hour

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