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A double-blind clinical trial is needed now, McDonald said, and it could be years before those results are available.

The current evidence suggests that GLP-1 RAs should be considered as part of a comprehensive obesity management strategy for adolescents who meet specific criteria, including failure of lifestyle interventions, presence of comorbidities, and adequate support systems

GLP-1 medications are not prescribed for patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2, during pregnancy or breastfeeding or when pregnancy is planned in the near term, with active pancreatitis or a history of pancreatic disease, or with severe gastroparesis or a significant gastrointestinal motility disorder